Originalarbeiten

 

2020

Nimtz L, Hartmann J, Tigges J, Masjosthusmann S, Schmuck M, Keßel E, Theiss S, Köhrer K, Petzsch P, Adjaye J, Wigmann C, Wieczorek D, Hildebrandt B, Bendt F, Hübenthal U, Brockerhoff G, Fritsche E. Characterization and application of electrically active neuronal networks established from human induced pluripotent stem cell-derived neural progenitor cells for neurotoxicity evaluation. Stem Cell Res (2020)

doi: 10.1016/j.scr.2020.101761

2019

Hausmann C, Zoschke C, Wolff C, Darvin ME, Sochorová M, Kováčik A, Wanjiku B, Schumacher F, Tigges J, Kleuser B, Lademann J, Fritsche E, Vávrová K, Ma N, Schäfer-Korting M. Fibroblast origin shapes tissue homeostasis, epidermal differentiation, and drug uptake. Sci Rep (2019)

doi: 10.1038/s41598-019-39770-6

Ali AAH, Schwarz-Herzke B, Mir S, Sahlender B, Victor M, Görg B, Schmuck M, Dach K, Fritsche E, Kremer A, von Gall C. Deficiency of the clock gene Bmal1 affects neural progenitor cell migration. Brain Struct Funct (2019)

doi: 10.1007/s00429-018-1775-1

Kühne BA, Puig T, Ruiz-Martí­nez S, Crous-Masó J, Planas M, Feliu L, Cano A, García ML, Fritsche E, Llobet JM, Gómez-Catalán J, Barenys M Comparison of migration disturbance potency of epigallocatechin gallate (EGCG) synthetic analogs and EGCG PEGylated PLGA nanoparticles in rat neurospheres. Food Chem Toxicol (2019)

doi: 10.1016/j.fct.2018.10.055

Li L, Yin Tang L, Liang B, Wang R, Sun Q, Bik San Lau C, Chung Leung P, Fritsche E, Liebsch M, Seiler Wulczyn AEM, Spielmann H, Wang CC. Evaluation of in vitro embryotoxicity tests for Chinese herbal medicines. Reprod Toxicol (2019)

doi: 10.1016/j.reprotox.2019.06.001

Walter KM, Dach K, Hayakawa K, Giersiefer S, Heuer H, Lein PJ, Fritsche E. Ontogenetic expression of thyroid hormone signaling genes: An in vitro and in vivo species comparison. PLos One (2019)

doi: 10.1371/journal.pone.0221230

Masjosthusmann S, Siebert C, Hübenthal U, Bendt F, Baumann J, Fritsche E. Arsenite interrupts neurodevelopmental processes of human and rat neural progenitor cells: The role of reactive oxygen species and species-specific antioxidative defense. Chemosphere (2019)

doi: 10.1016/j.chemosphere.2019.06.123

2018

Hellwig C, Barenys M, Baumann J, Gassmann K, Casanellas L, Kauer G, Fritsche E. Culture of human neurospheres in 3D scaffolds for developmental neurotoxicity testing. Toxicol In Vitro (2018)

doi: 10.1016/j.tiv.2018.06.002

Masjosthusmann S, Becker D, Petzuch B, Klose J, Siebert C, Deenen R, Barenys M, Baumann J, Dach K, Tigges J, Hübenthal U, Köhrer K, Fritsche E. A transcriptome comparison of time-matched developing human, mouse and rat neural progenitor cells reveals human uniqueness. Toxicol Appl Pharmacol (2018)

doi: 10.1016/j.taap.2018.05.009

2017

Barenys M, Gassmann K, Baksmeier C, Heinz S, Reverte I, Schmuck M, Temme T, Bendt F, Zschauer TC, Rockel TD, Unfried K, Wätjen W, Sundaram SM, Heuer H, Colomina MT, Fritsche E. Epigallocatechin gallate (EGCG) inhibits adhesion and migration of neural progenitor cells in vitro. Arch Toxicol (2017)

doi: 10.1007/s00204-016-1709-8

Schmuck MR, Temme T, Dach K, de Boer D, Barenys M, Bendt F, Mosig A, Fritsche E. Omnisphero: a high-content image analysis (HCA) approach for phenotypic developmental neurotoxicity (DNT) screenings of organoid neurosphere cultures in vitro. Arch Toxicol (2017)

doi: 10.1007/s00204-016-1852-2

Dach K, Bendt F, Huebenthal U, Giersiefer S, Lein PJ, Heuer H, Fritsche E. BDE-99 impairs differentiation of human and mouse NPCs into the oligodendroglial lineage by species-specific modes of action. Sci Rep (2017)

doi: 10.1038/srep44861

Hofrichter M, Nimtz L, Tigges J, Kabiri Y, Schröter F, Royer-Pokora B, Hildebrandt B, Schmuck M, Epanchintsev A, Theiss S, Adjaye J, Egly JM, Krutmann J, Fritsche E. Comparative performance analysis of human iPSC-derived and primary neural progenitor cells (NPC) grown as neurospheres in vitro. Stem Cell Res (2017)

doi: 10.1016/j.scr.2017.10.013

2016

Baumann J, Gassmann K, Masjosthusmann S, DeBoer D, Bendt F, Giersiefer S, Fritsche E. Comparative human and rat neurospheres reveal species differences in chemical effects on neurodevelopmental key events. Arch Toxicol (2016)

doi: 10.1007/s00204-015-1568-8

2014

Tigges J, Haarmann-Stemmann T, Vogel CFA, Grindel A, Hübenthal U, Brenden H, Grether-Beck S, Vielhaber G, Johncock W, Krutmann J, Fritsche E. The new aryl hydrocarbon receptor antagonist E/Z-2-benzylindene-5,6-dimethoxy-3,3-dimethylindan-1-one protects against UVB-induced signal transduction. J Invest Dermatol (2014)

doi: 10.1038/jid.2013.362

Baumann J, Barenys M, Gassmann K, Fritsche E. Comparative human and rat neurosphere assay for developmental neurotoxicity testing. Curr Protoc Toxicol (2014)

doi: 10.1002/0471140856.tx1221s59

Schmuck M, Temme T, Heinz S, Baksmeier C, Mosig A, Colomina MT, Barenys M, Fritsche E. Automatic counting and positioning of 5-bromo-2-deoxyuridine (BrdU) positive cells in cortical layers of rat brain slices. Neurotoxicology (2014)

doi: 10.1016/j.neuro.2014.02.005

Gassmann K, Schreiber T, Dingemans MM, Krause G, Roderigo C, Giersiefer S, Schuwald J, Moors M, Unfried K, Bergman Å, Westerink RH, Rose CR, Fritsche E. BDE-47 and 6-OH-BDE-47 modulate calcium homeostasis in primary fetal human neural progenitor cells via ryanodine receptor-independent mechanisms. Arch Toxicol (2014)

doi: 10.1007/s00204-014-1217-7

2013

Tigges J, Weighardt H, Wolff S, Götz C, Förster I, Kohne Z, Huebenthal U, Merk HF, Abel J, Haarmann-Stemmann T, Krutmann J, Fritsche E. Aryl hydrocarbon receptor repressor (AhRR) function revisited: repression of CYP1 activity in human skin fibroblasts is not related. to AhRR expression J Invest Dermatol (2013)

doi: 10.1038/jid.2012.259

Hewitt NJ, Edwards RJ, Fritsche E, Goebel C, Aeby P, Scheel J, Reisinger K, Ouédraogo G, Duche D, Eilstein J, Latil A, Kenny J, Moore C, Kuehnl J, Barroso J, Fautz R, Pfuhler S. Use of human in vitro skin models for accurate and ethical risk assessment: metabolic considerations. Toxicol Sci (2013)

doi: 10.1093/toxsci/kft080

2012

van Eijl S, Zhu Z, Cupitt J, Gierula M, Götz C, Fritsche E, Edwards RJ. Elucidation of xenobiotic metabolism pathways in human skin and human skin models by proteomic profiling. Cell Mol Life Sci (2012)

doi: 10.1371/journal.pone.0041721

Götz C, Pfeiffer R, Tigges J, Blatz V, Jäckh C, Freytag EM, Fabian E, Landsiedel R, Merk HF, Krutmann J, Edwards RJ, Pease C, Goebel C, Hewitt N, Fritsche E. Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I). Exp Dermatol (2012)

doi: 10.1111/j.1600-0625.2012.01486.x

Götz C, Pfeiffer R, Tigges J, Ruwiedel K, Hübenthal U, Merk HF, Krutmann J, Edwards RJ, Abel J, Pease C, Goebel C, Hewitt N, Fritsche E. Xenobiotic metabolism capacities of human skin in comparison with a 3D-epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: phase II enzymes. Exp Dermatol (2012)

doi: 10.1111/j.1600-0625.2012.01478.x

Röck K, Meusch M, Fuchs N, Tigges J, Zipper P, Fritsche E, Krutmann J, Homey B, Reifenberger J, Fischer JW.     Estradiol protects dermal hyaluronan/versican matrix during photoaging by release of epidermal growth factor from keratinocytes. J Biol Chem (2012)

doi: 10.1074/jbc.M112.353151

Götz C, Hewitt NJ, Jermann E, Tigges J, Kohne Z, Hübenthal U, Krutmann J, Merk HF, Fritsche E. Effects of the genotoxic compounds, benzo[a]pyrene and cyclophosphamide on phase 1 and 2 activities in EpiDermâ„¢ models. Xenobiotica (2012)

doi: 10.3109/00498254.2011.643255

2011

Tegenge MA, Rockel TD, Fritsche E, Bicker G. Nitric oxide stimulates human neural progenitor cell migration via cGMP-mediated signal transduction. Cell Mol Life Sci (2011)

doi: 10.1007/s00018-010-0554-9

2010

Schreiber T, Gassmann K, Götz C, Hübenthal U, Moors M, Krause G, Merk HF, Nguyen NH, Scanlan TS, Abel J, Rose CR, Fritsche E. Polybrominated diphenyl ethers induce developmental neurotoxicity in a human in vitro model: evidence for endocrine disruption. Environ Health Perspect (2010)

doi: 10.1289/ehp.0901435

Gassmann K, Abel J, Bothe H, Haarmann-Stemmann T, Merk HF, Quasthoff KN, Rockel TD, Schreiber T, Fritsche E. Species-specific differential AhR expression protects human neural progenitor cells against developmental neurotoxicity of PAHs. Environ Health Perspect (2010)

doi: 10.1289/ehp.0901545

2009

Moors M, Rockel TD, Abel J, Cline JE, Gassmann K, Schreiber T, Schuwald J, Weinmann N, Fritsche E. Human neurospheres as three-dimensional cellular systems for developmental neurotoxicity testing. Environ Health Perspect (2009)

doi: 10.1289/ehp.0800207

2007

Moors M, Cline JE, Abel J, Fritsche E. ERK-dependent and -independent pathways trigger human neural progenitor cell migration. Toxicol Appl Pharmacol (2007)

doi: 10.1016/j.taap.2007.02.018

Fritsche E, Schäfer C, Calles C, Bernsmann T, Bernshausen T, Wurm M, Hübenthal U, Cline JE, Hajimiragha H, Schroeder P, Klotz LO, Rannug A, Fürst P, Hanenberg H, Abel J, Krutmann J. Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation. Proc Natl Acad Sci (2007)

doi: 10.1073/pnas.0701764104

2005

Fritsche E, Cline JE, Nguyen NH, Scanlan TS, Abel J. Polychlorinated biphenyls disturb differentiation of normal human neural progenitor cells: clue for involvement of thyroid hormone receptors. Environ Health Perspect (2005)

doi: 10.1289/ehp.7793
 

 

Wissenschaftliche Stellungnahmen/Berichte

 

 

2020

Lupu D, Andersson P, Bornehag CG, Demeneix B, Fritsche E, Gennings C, Lichtensteiger W, Leist M, Leonards PEG, Ponsonby AL, Scholze M, Testa G, Tresguerres JAF, Westerink RHS, Zalc B, Rüegg J. The ENDpoiNTs Project: Novel Testing Strategies for Endocrine Disruptors Linked to Developmental Neurotoxicity. Int J Mol Sci (2020)

doi: 10.3390/ijms21113978

2019

Lanzoni A, Castoldi AF, Kass GEN, Terron A, De Seze G, Bal-Price A, Bois FY, Delclos KB, Doerge DR, Fritsche E, Halldorsson T, Kolossa-Gehring M, Bennekou SH, Koning F, Lampen A, Leist M, Mantus E, Rousselle C, Siegrist M, Steinberg P, Tritscher A, Van de Water B, Vineis P, Walker N, Wallace H, Whelan M, Younes M. Advancing human health risk assessment. EFSA Journal (2019)

 https://doi.org/10.2903/j.efsa.2019.e170712

Krebs A, Waldmann T, Wilks MF, Van Vugt-Lussenburg BMA, Van der Burg B, Terron A, Steger-Hartmann T, Ruegg J, Rovida C, Pedersen E, Pallocca G, Luijten M, Leite SB, Kustermann S, Kamp H, Hoeng J, Hewitt P, Herzler M, Hengstler JG, Heinonen T, Hartung T, Hardy B, Gantner F, Fritsche E, Fant K, Ezendam J, Exner T, Dunkern T, Dietrich DR, Coecke S, Busquet F, Braeuning A, Bondarenko O, Bennekou SH, Beilmann M, Leist M. Template for the description of cell-based toxicological test methods to allow evaluation and regulatory use of the data. ALTEX (2019)

doi: 10.14573/altex.1909271

Solecki R, Rauch M, Gall A, Buschmann J, Kellner R, Kucheryavenko O, Schmitt A, Delrue N, Li W, Hu J, Fujiwara M, Kuwagata M, Mantovani A, Makris SL, Paumgartten F, Schönfelder G, Schneider S, Vogl S, Kleinstreuer N, Schneider M, Schulze F, Fritsche E, Clark R, Shiota K, Chahoud I. Update of the DevTox data database for harmonized risk assessment and alternative methodologies in developmental toxicology: Report of the 9th Berlin Workshop on Developmental Toxicity. Reprod Toxicol (2019)

doi: 10.1016/j.reprotox.2019.07.003

2018

Masjosthusmann S, Barenys M, El-Gamal M, Geerts L, Gerosa L, Gorreja A, Kühne B, Marchetti N, Tigges J, Viviani B, Witters H, Fritsche E. Literature review and appraisal on alternative neurotoxicity testing methods. EFSA Journal (2018)

https://doi.org/10.2903/sp.efsa.2018.EN-1410

Fritsche E, Grandjean P, Crofton KM, Aschner M, Goldberg A, Heinonen T, Hessel EVS, Hogberg HT, Bennekou SH, Lein PJ, Leist M, Mundy WR, Paparella M, Piersma AH, Sachana M, Schmuck G, Solecki R, Terron A, Monnet-Tschudi F, Wilks MF, Witters H, Zurich MG, Bal-Price A. Consensus statement on the need for innovation, transition and implementation of developmental neurotoxicity (DNT) testing for regulatory purposes. Toxicol Appl Pharmacol (2018)

doi: 10.1016/j.taap.2018.02.004

Bal-Price A, Hogberg HT, Crofton KM, Daneshian M, FitzGerald RE, Fritsche E, Heinonen T, Hougaard Bennekou S, Klima S, Piersma AH, Sachana M, Shafer TJ, Terron A, Monnet-Tschudi F, Viviani B, Waldmann T,  Westerink RHS, Wilks MF, Witters H, Zurich MG, Leist M. Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity. ALTEX (2018)

doi: 10.14573/altex.1712081

Bal-Price A, Fritsche E. Editorial: Developmental neurotoxicity. Toxicol Appl Pharmacol (2018)

doi: 10.1016/j.taap.2018.07.016

 

2017

Aschner M, Ceccatelli S, Daneshian M, Fritsche E, Hasiwa N, Hartung T, Hogberg HT, Leist M, Li A, Mundi WR, Padilla S, Piersma AH, Bal-Price A, Seiler A, Westerink RH, Zimmer B, Lein PJ. Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: example lists and criteria for their selection and use. ALTEX (2017)

doi: 10.14573/altex.1604201

 

Fritsche E, Crofton KM, Hernandez AF, Hougaard Bennekou S, Leist M, Bal-Price A, Reaves E, Wilks MF, Terron A, Solecki R, Sachana M, Gourmelon A. OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes. ALTEX (2017)

doi: 10.14573/altex.1701171

 

 

2016

Benfenati E, Berggren E, Fritsche E, Hartung T, Slikker W, Spielmann H, Testai E, Tice RR, Tiramani M, Villenave R. Novel chemical hazard characterisation approaches. EFSA Journal (2016)

https://doi.org/10.2903/j.efsa.2016.s0506

 

2015

Fritsche E, Alm H, Baumann J, Geerts L, Hakansson H, Masjosthusmann S, Witters H. Literature review on in vitro and alternative Developmental Neurotoxicity (DNT) testing methods. EFSA Journal (2015)

https://doi.org/10.2903/sp.efsa.2015.EN

 

Bal-Price A, Crofton KM, Leist M, Allen S, Arand M, Buetler T, Delrue N, FitzGerald RE, Hartung T, Heinonen T, Hogberg H, Bennekou SH, Lichtensteiger W, Oggier D, Paparella M, Axelstad M, Piersma A, Rached E, Schilter B, Schmuck G, Stoppini L, Tongiorgi E, Tiramani M, Monnet-Tschudi F, Wilks MF, Ylikomi T, Fritsche E. International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes. Arch Toxicol (2015)

doi: 10.1007/s00204-015-1464-2

de Boer J, Fritsche E, Schoeters G, Kimber I. The European Long-range Research Initiative (LRI): A decade of contributions to human health protection, exposure modelling and environmental integrity. Toxicology (2015)

doi: 10.1016/j.tox.2015.09.003

 

2014

Crofton K, Fritsche E, Ylikomi T, Bal-Price A. International Stakeholder NETwork (ISTNET) for creating a developmental neurotoxicity testing (DNT) roadmap for regulatory purposes. ALTEX (2014)

doi: 10.14573/altex.1402121

2012

Bal-Price AK, Coecke S, Costa L, Crofton KM, Fritsche E, Goldberg A, Grandjean P, Lein PJ, Li A, Lucchini R, Mundy WR, Padilla S, Persico AM, Seiler AE, Kreysa J. Advancing the science of developmental neurotoxicity (DNT): testing for better safety evaluation. ALTEX (2012)

doi: 10.14573/altex.2012.2.202

 

Adverse Outcome Pathways

 

 

2018

Terron A, Bal-Price A, Paini A, Monnet-Tschudi F, Bennekou SH; EFSA WG EPI1 Members, Leist M, Schildknecht S. An adverse outcome pathway for parkinsonian motor deficits associated with mitochondrial complex I inhibition. Arch Toxicol (2018)

doi: 10.1007/s00204-017-2133-4

2017

Ockleford C, Adriaanse P, Berny P, Brock T, Duquesne S, Grilli S, Hernandez-Jerez AF, Hougaard Bennekou S, Klein M, Kuhl T, Laskowski R, Machera K, Pelkonen O, Pieper S, Smith R, Stemmer M, Sundh I, Teodorovic I, Tiktak A, Topping CJ, Wolterink G, Angeli K, Fritsche E, Hernandez-Jerez AF, Leist M, Montovani A, Mendendez P, Pelkonen O, Price A, Viviani B, Chiusolo A, Ruffo F, Terron A, Hougaard Bennekou S. Investigation into experimental toxicological properties of plant protection products having a potential link to Parkinson's disease and childhood leukaemia. EFSA Journal (2017)

https://doi.org/10.2903/j.efsa.2017.4691

Pelkonen O, Terron A, Hernandez AF, Menendez P, Bennekou SH; EFSA WG EPI1 and its other members. Chemical exposure and infant leukaemia: development of an adverse outcome pathway (AOP) for aetiology and risk assessment research. Arch Toxicol (2017)

doi: 10.1007/s00204-017-1986-x

Bal-Price A, Lein PJ, Keil KP, Sethi S, Shafer T, Barenys M, Fritsche E, Sachana M, Meek MEB. Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity. Neurotoxicology (2017)

doi: 10.1016/j.neuro.2016.05.010

2015

Bal-Price A, Crofton KM, Sachana M, Shafer TJ, Behl M, Forsby A, Hargreaves A, Landesmann B, Lein PJ, Louisse J, Monnet-Tschudi F, Paini A, Rolaki A, Schrattenholz A, Sunol C, van Thriel C, Whelan M, Fritsche E. Putative adverse outcome pathways relevant to neurotoxicity. Crit Rev Toxicol (2015)

doi: 10.3109/10408444.2014.981331

 

Übersichtsarbeiten

 

 

2020

 

Barenys M, Reverte I, Masjosthusmann S, Gómez-Catalán J, Fritsche E. Developmental neurotoxicity of MDMA. A systematic literature review summarized in a putative adverse outcome pathway. Neurotoxicology (2020)

doi: 10.1016/j.neuro.2019.12.007

Fritsche E, Tigges J, Hartmann J, Kapr J, Serafini MM, Viviani B. Neural In Vitro Models for Studying Substances Acting on the Central Nervous System. Brain Struct Funct (2020)

doi: 10.1007/164_2020_367

2018

Barenys M, Fritsche E. A Historical Perspective on the Use of Stem/Progenitor Cell-Based In Vitro Methods for Neurodevelopmental Toxicity Testing. Toxicol Sci (2018)

doi: 10.1093/toxsci/kfy170

Fritsche E, Barenys M, Klose J, Masjosthusmann S, Nimtz L, Schmuck M, Wuttke S, Tigges J. Current Availability of Stem Cell-Based In Vitro Methods for Developmental Neurotoxicity (DNT) Testing. Toxicol Sci (2018)

doi: 10.1093/toxsci/kfy178

Fritsche E, Barenys M, Klose J, Masjosthusmann S, Nimtz L, Schmuck M, Wuttke S, Tigges J. Development of the Concept for Stem Cell-Based Developmental Neurotoxicity Evaluation. Toxicol Sci (2018)

doi: 10.1093/toxsci/kfy175

Baker N, Boobis A, Burgoon L, Carney E, Currie R, Fritsche E, Knudsen T, Laffont M, Piersma AH, Poole A, Schneider S, Daston G. Building a developmental toxicity ontology. Birth Defects Res (2018)

doi: 10.1002/bdr2.1189

2017

Barenys M, Masjosthusmann S, Fritsche E. Is Intake of Flavonoid-Based Food Supplements During Pregnancy Safe for the Developing Child? A Literature Review. Curr Drug Targets (2017)

doi: 10.2174/1389450116666150804110049

2014

Alépée N, Bahinski A, Daneshian M, De Wever B, Fritsche E, Goldberg A, Hansmann J, Hartung T, Haycock J, Hogberg H, Hoelting L, Kelm JM, Kadereit S, McVey E, Landsiedel R, Leist M, Lübberstedt M, Noor F, Pellevoisin C, Petersohn D, Pfannenbecker U, Reisinger K, Ramirez T, Rothen-Rutishauser B, Schäfer-Korting M, Zeilinger K, Zurich MG. State-of-the-art of 3D cultures (organs-on-a-chip) in safety testing and pathophysiology. ALTEX (2014)

doi: 10.14573/altex.1406111

Tigges J, Krutmann J, Fritsche E, Haendeler J, Schaal H, Fischer JW, Kalfalah F, Reinke H, Reifenberger G, Stühler K, Ventura N, Gundermann S, Boukamp P, Boege F. The hallmarks of fibroblast ageing. Mech Ageing Dev (2014)

doi: 10.1016/j.mad.2014.03.004

2011

Fritsche E, Gassmann K, Schreiber T. Neurospheres as a model for developmental neurotoxicity testing. Methods Mol Biol (2011)

doi: 10.1007/978-1-61779-170-3_7

Verner MA, Bouchard M, Fritsche E, Charbonneau M, Haddad S. In vitro neurotoxicity data in human risk assessment of polybrominated diphenyl ethers (PBDEs): overview and perspectives. Toxicol In Vitro (2011)

doi: 10.1016/j.tiv.2011.06.007

2010

Breier JM, Gassmann K, Kayser R, Stegeman H, De Groot D, Fritsche E, Shafer TJ. Neural progenitor cells as models for high-throughput screens of developmental neurotoxicity: state of the science. Neurotoxicol Teratol (2010)

doi: 10.1016/j.ntt.2009.06.005